same here, doesnt work for me, doesnt work for my colleagues. You have to restart the application to see the plugin changes. The list in PluginManager.ReferencedPlugins isn't updated after a plugin is installed or uninstalled. I haven't investigated further, but we are not the only ones who have this issue.
This is confirmed in Nop 4.1 as well. I am on VS2017 running with IISexpress. Plugin gets installed properly. However the [configure] button doesn't get displayed until I stop and restart.