I assume you are using latest nopCommerce version. You should enable debugging by setting the value in web.config and then see the logs to see the error details.
Please paste them here so we can know more about it.
Try to check error logs so you will get idea that from where its broken. on admin side you can check it at /admin/log/list or you can directly check on the database by firing query like SELECT * FROM [Log] ORDER BY ID DESC
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