I configured my development environment and installed the plugins I needed and among them "Nop.Plugin.Pickup.PickupInStore".
Later I published the site in a Staging environment (which uses the same Database).
In admin the Plugins figured as NOT installed and I proceeded to reinstall them one by one with a subsequent restart of the application.
When I installed "Nop.Plugin.Pickup.PickupInStore" this error appeared on restart:
An error occurred while starting the application.
.NET Core 4.6.28008.02 X64 v184.108.40.206 | Microsoft.AspNetCore.Hosting version 2.2.0-rtm-35687 | Microsoft Windows 10.0.17763
Thanks to this article: https://www.nop-templates.com/troubleshooting-guide I could understand that a dbo.StorePickupPoint table creation command was executed without a check that the table already existed with a consequent error.
Actually I understood after the plugins were all already installed and I solved simply by bringing the plugin.js file into STAGING as well
I hope this helps others