I can't think of a good reason for every nopCommerce store not to use this plugin. I guess if a user wanted to delete several lines from their cart all at once the original checkbox/update cart method might save some page reloads but personally, I rarely do that when I am shopping online. It is usually only a line or 2 that I will delete and this button saves the user the extra click.
After installation, it initially did not work with our Nop-Templates theme. I emailed the developer on a Saturday night. Within about an hour I got a follow up email explaining that they discovered the issue was because of an update to our theme. Within the hour I received another email saying the issue was fixed and to download the updated version. I did and it works perfectly. Highly recommend the plugin and this team.