Fout by debug

I recieve always by running local (in debug) a message:
Access to the path 'C:\..\AppData\Local\Temp\Temporary ASP.NET Files\root\3c78f072\e8917b35\SevenSpikes.Nop.Plugins.Core.dll' is denied.

If I clean solution and rebuild then everything is working but till the next time. My site is also online, there I recieve :

"This page isn’t working
beta.mobileaccess.be:4040 didn’t send any data.
ERR_EMPTY_RESPONSE "

How can I resolve this problem?

Anakondra wrote:

May be issue with NopTemplates plugin. Please ask for support to the team. OR they're having separate forum so you can ask there also.

Thete is not possible to add a new theme in the forum !