content\images\thumbs\0224334_productname.jpeg
Let's say we're up to 224,334 images in the thumbs folder. That's a lot of files for a single folder. This will cause problems with FTP software and any type of directory browsing. This is not that big of a deal actually since the image files will be added & deleted via nopcommerce.
We'll also be using MaxCDN and they've confirmed that all those images in a single folder is no problem. Arvixe hosting should be fine with this since the images will be served from a CDN.
Does this all sound like a good strategy?