I've tried Recycling the App Pool, Clearing the Cache, Restarting the Application, Restarting the server, and fiddling with the IIS settings.
The full stack trace is:
System.OutOfMemoryException: Exception of type 'System.OutOfMemoryException' was thrown. at System.RuntimeTypeHandle.GetTypeByName(String name, Boolean throwOnError, Boolean ignoreCase, Boolean reflectionOnly, StackCrawlMarkHandle stackMark, IntPtr pPrivHostBinder, Boolean loadTypeFromPartialName, ObjectHandleOnStack type) at System.RuntimeTypeHandle.GetTypeByName(String name, Boolean throwOnError, Boolean ignoreCase, Boolean reflectionOnly, StackCrawlMark& stackMark, IntPtr pPrivHostBinder, Boolean loadTypeFromPartialName) at System.RuntimeType.GetType(String typeName, Boolean throwOnError, Boolean ignoreCase, Boolean reflectionOnly, StackCrawlMark& stackMark) at System.Type.GetType(String typeName, Boolean throwOnError, Boolean ignoreCase) at ImageResizer.Configuration.PluginConfig.FindPluginType(String searchName) at ImageResizer.Configuration.PluginConfig.add_plugin_by_name(String name, NameValueCollection args) at ImageResizer.Configuration.PluginConfig.loadPluginsInternal() at ImageResizer.Configuration.PluginConfig.LoadPlugins() at ImageResizer.Configuration.Config.get_Current() at Nop.Services.Media.PictureService.ValidatePicture(Byte[] pictureBinary, String mimeType) at Nop.Services.Media.PictureService.InsertPicture(Byte[] pictureBinary, String mimeType, String seoFilename, String altAttribute, String titleAttribute, Boolean isNew, Boolean validateBinary) at Nop.Admin.Controllers.PictureController.AsyncUpload() at lambda_method(Closure , ControllerBase , Object[] ) at System.Web.Mvc.ReflectedActionDescriptor.Execute(ControllerContext controllerContext, IDictionary`2 parameters) at System.Web.Mvc.ControllerActionInvoker.InvokeActionMethod(ControllerContext controllerContext, ActionDescriptor actionDescriptor, IDictionary`2 parameters) at System.Web.Mvc.Async.AsyncControllerActionInvoker.<BeginInvokeSynchronousActionMethod>b__39(IAsyncResult asyncResult, ActionInvocation innerInvokeState) at System.Web.Mvc.Async.AsyncResultWrapper.WrappedAsyncResult`2.CallEndDelegate(IAsyncResult asyncResult) at System.Web.Mvc.Async.AsyncControllerActionInvoker.EndInvokeActionMethod(IAsyncResult asyncResult) at System.Web.Mvc.Async.AsyncControllerActionInvoker.AsyncInvocationWithFilters.<InvokeActionMethodFilterAsynchronouslyRecursive>b__3d() at System.Web.Mvc.Async.AsyncControllerActionInvoker.AsyncInvocationWithFilters.<>c__DisplayClass46.<InvokeActionMethodFilterAsynchronouslyRecursive>b__3f() at System.Web.Mvc.Async.AsyncControllerActionInvoker.AsyncInvocationWithFilters.<>c__DisplayClass46.<InvokeActionMethodFilterAsynchronouslyRecursive>b__3f() at System.Web.Mvc.Async.AsyncControllerActionInvoker.AsyncInvocationWithFilters.<>c__DisplayClass46.<InvokeActionMethodFilterAsynchronouslyRecursive>b__3f() at System.Web.Mvc.Async.AsyncControllerActionInvoker.AsyncInvocationWithFilters.<>c__DisplayClass46.<InvokeActionMethodFilterAsynchronouslyRecursive>b__3f() at System.Web.Mvc.Async.AsyncControllerActionInvoker.AsyncInvocationWithFilters.<>c__DisplayClass46.<InvokeActionMethodFilterAsynchronouslyRecursive>b__3f() at System.Web.Mvc.Async.AsyncControllerActionInvoker.EndInvokeActionMethodWithFilters(IAsyncResult asyncResult) at System.Web.Mvc.Async.AsyncControllerActionInvoker.<>c__DisplayClass21.<>c__DisplayClass2b.<BeginInvokeAction>b__1c() at System.Web.Mvc.Async.AsyncControllerActionInvoker.<>c__DisplayClass21.<BeginInvokeAction>b__1e(IAsyncResult asyncResult) at System.Web.Mvc.Async.AsyncControllerActionInvoker.EndInvokeAction(IAsyncResult asyncResult) at System.Web.Mvc.Controller.<BeginExecuteCore>b__1d(IAsyncResult asyncResult, ExecuteCoreState innerState) at System.Web.Mvc.Async.AsyncResultWrapper.WrappedAsyncVoid`1.CallEndDelegate(IAsyncResult asyncResult) at System.Web.Mvc.Controller.EndExecuteCore(IAsyncResult asyncResult) at System.Web.Mvc.Async.AsyncResultWrapper.WrappedAsyncVoid`1.CallEndDelegate(IAsyncResult asyncResult) at System.Web.Mvc.Controller.EndExecute(IAsyncResult asyncResult) at System.Web.Mvc.MvcHandler.<BeginProcessRequest>b__5(IAsyncResult asyncResult, ProcessRequestState innerState) at System.Web.Mvc.Async.AsyncResultWrapper.WrappedAsyncVoid`1.CallEndDelegate(IAsyncResult asyncResult) at System.Web.Mvc.MvcHandler.EndProcessRequest(IAsyncResult asyncResult) at System.Web.HttpApplication.CallHandlerExecutionStep.System.Web.HttpApplication.IExecutionStep.Execute() at System.Web.HttpApplication.ExecuteStep(IExecutionStep step, Boolean& completedSynchronously)