We are getting the error Sys is undefined error ScriptResource.axd line 2 in the Administration section when trying to view product details. If I connect to the hosting site from development env I can view everything fine. However if I login to the admin section through hosting account we see this error. We just moved to production, please let us know how to resolve the issue.
I had this problem before on a website I was developing...not with nopCommerce though. The problem was that the URL Rewrite module does not work well with Ajax control toolkit. This may be your issue too. I never did find a solution for it...I just took away the URL rewrite module.
The issue arises when I changed the IIs setttings for our 404 pages to our default page. Once you do that the problem starts if you don't do custom errors for 404 everything works fine. I spend some time on that last night. Hope this will be useful information for others.