Which port are you using in your store's email account settings?
https://github.com/nopSolutions/nopCommerce/issues/4447
https://github.com/nopSolutions/nopCommerce/issues/4447
make sure that you are using correct protocol ports: 465 with SSL security or 587 with TLS by default
I have SSL enabled in my mail settings, and I'm using the port 465 :s