V4.50.3 to V4.60.5?

How do I accomplish this?

There are instructions
See https://docs.nopcommerce.com/en/installation-and-upgrading/upgrading-nopcommerce.html

But I always start with a fresh directory
Copy in the system minus the appsettings.json and plugins.json config files
Run the install and create a test database and check everything works
Then you can change the appsettings.json file to point to your database
Migrations will upgrade your database (providing it not customised)
Then install pluigns and configure the system

Want to add to the previous post that you need to make sure the plugin version to the latest version as well.